Comparison of autologous and allogeneic stem cell transplantation for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

نویسندگان

چکیده

Objectives To analyze the outcomes of patients who received autologous stem cell transplantation (auto-SCT), matched sibling donor (MSD-SCT) and haploidentical (haplo-SCT) provide basis for choice method in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).Methods We retrospectively investigated 119 adult with Ph+ ALL our center. The overall survival (OS) rate, leukemia-free (LFS) cumulative incidence relapse (CIR) non-relapse mortality (NRM) rate impact achievement complete molecular response (CMR) within 3 months sustaining CMR up to (s3CMR) on were explored.Results estimated OS, LFS, CIR NRM rates at years not significantly different among three groups (p = 0.960, 0.917, 0.375 0.096, respectively). For 65 achieved s3CMR, there was no significant difference OS (84.5% vs 72.5% 100%, p 0.374), LFS (75.2% 64.5% 83.3%, 0.668), (17.2% 8.1% 16.7%, 0.583) (3.1% 23.4% 0%, 0.055) auto-SCT group, MSD-SCT group haplo-SCT group. However, did achieve recipients tended have higher (60% 33.2% 24.0%, 0.013) than allo-HSCT group.Conclusions Auto-SCT maintenance therapy after HSCT appears be an attractive treatment option especially those whose s3CMR kept transplantation. non-s3CMR patients, allogeneic may more effective from lower relapse.

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ژورنال

عنوان ژورنال: Hematology

سال: 2021

ISSN: ['1520-4391', '1520-4383']

DOI: https://doi.org/10.1080/16078454.2020.1868783